Nazwa produktu: Goserelin
Synonimy: SÓL OCTANA GOSERELINY;(D-BE(TBU)6,AZAGLY10)-OCTAN UWALNIAJĄCY HORMON UWALNIAJĄCY GONADOTROPINĘ;(D-BE(TBU)6,AZAGLY10)-SÓL OCTANOWA LHRH;(D-BE(TBU)6,AZAGLY10)-SÓL OCTANOWA CZYNNIKA UWALNIAJĄCEGO HORMON LUTEINIZUJĄCY;(D-BE(TBU)6,AZAGLY10)-SÓL OCTANOWA HORMONA UWALNIAJĄCEGO HORMON LUTEINIZUJĄCY;PYR-HIS-TRP-SER-TYR-D-SER(TBU)-SÓL OCTANOWA LEU-ARG-PRO-AZAGLY-NH2;2-(aminokarbonyl)hydrazyd;decapeptidei
CAS: 65807-02-5
MF: C61H88N18O16
MW: 1329.46
Goserelin is an analog of luteinizing hormone-releasing hormone (LHRH) useful in the treatment of malignancies responsive to hormonal manipulation. Administered parenterally in a biodegradable depot, goserelin is reportedly as effective as orchidectomy and oophorectomy in patients with advanced prostate carcinoma and pre-menopausal breast cancer.
1. Gonadorelina to inna nazwa hormonu uwalniającego gonadotropinę (GnRH). Jest to syntetyczny dekapeptyd wytwarzany metodą syntezy peptydów w fazie stałej. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
2. GnRH jest dostępny w postaci chlorowodorku gonadoreliny )oraz tetrahydrat dioctanu gonadoreliny do wstrzykiwań. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. Stosowany jest także w weterynarii w leczeniu bydła cierpiącego na torbielowatość jajników.
3. Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.
Mężczyźni
Palliative treatment of advanced carcinoma of the prostate; in combination with flutamide for management of locally confined stage T2b to T4 (stage B2 to C) carcinoma of the prostate.
Kobiety (3.6 mg only)
Palliative treatment of advanced breast cancer in pre- and perimenopausal women; treatment of endometriosis; as an endometrial thinning agent prior to endometrial ablation for dysfunctional uterine bleeding.
