Nom du produit:Lévothyroxine sodique
CAS:55-03-8
MF:C15H20I4NNaO9
MW:888.93
EINECS:200-221-4
Fichier Mol:55-03-8.mol Point de fusion:207-210 (déc.)(allumé.)
alpha D20 -4,4° (c = 3 dans 70% éthanol)
Densité d420 2.381
température de stockage. 2-8°C
Thyroxine Soduim Salt is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine
This product is thyroid hormone replacement therapy. Function and application: It is a synthetic sodium salt of IV-thyronine. Its function and application are similar to that of thyroid tablets. Its oral absorption is 50%, its onset is slow, steady and similar to physiological hormone, which is suitable for the substitution therapy of thyroid hormone. For simple goiter, and thyroidectomy after taking, can prevent the recurrence of goiter, but also can be used as a variety of causes of hypothyroidism and other supplementary treatment.
| Caractéristiques |
White or pale yellow crystalline powder |
Conforme |
| Identification |
Par IR |
Conforme |
|
Par HPLC |
Conforme |
| Solubilité |
Soluble in acid and alkali solution and water, slightly soluble in ethanol, insoluble in chloroform and ether |
Conforme |
| Rotation spécifique |
-5.0°~-6.0° |
-5.2° |
| Teneur en eau |
≤11.0% |
7.2% |
| Iodides Content |
≤0.08% |
Conforme |
| Substances associées |
Liothyronine: ≤2.00% |
0.20% |
|
N-Acetyl-T4: ≤0,20% |
0.10% |
|
Any other individual impurity: ≤0,50% |
Conforme |
|
Impuretés totales: ≤2.00% |
1.08% |
Essai
(Base HPLC sur séchage) |
97.0%~103,0% |
99.7% |
| Norme de référence |
Norme interne |
| Conclusion |
Le produit est conforme à la norme interne. |
| Stockage |
Conserver bien serré,contenants résistants à la lumière dans un endroit frais |
