Название продукта:Levothyroxine sodium
КАС:55-03-8
МФ:C15H20I4NNaO9
МВт:888.93
ЭИНЭКС:200-221-4
Мол Файл:55-03-8.моль Температура плавления:207-210 (декабрь)(горит.)
alpha D20 -4.4° (c = 3 in 70% этанол)
Density d420 2.381
температура хранения. 2-8°С
Thyroxine Soduim Salt is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (ТТГ). Deiodinated in peripheral tissues to the active metabolite, liothyronine
This product is thyroid hormone replacement therapy. Function and application: It is a synthetic sodium salt of IV-thyronine. Its function and application are similar to that of thyroid tablets. Its oral absorption is 50%, its onset is slow, steady and similar to physiological hormone, which is suitable for the substitution therapy of thyroid hormone. For simple goiter, and thyroidectomy after taking, can prevent the recurrence of goiter, but also can be used as a variety of causes of hypothyroidism and other supplementary treatment.
| Characteristics |
White or pale yellow crystalline powder |
Соответствует |
| Идентификация |
По ИК |
Соответствует |
|
By HPLC |
Соответствует |
| Растворимость |
Soluble in acid and alkali solution and water, slightly soluble in ethanol, insoluble in chloroform and ether |
Соответствует |
| Конкретное вращение |
-5.0°~-6.0° |
-5.2° |
| Содержание воды |
≤11.0% |
7.2% |
| Iodides Content |
≤0.08% |
Соответствует |
| Родственные вещества |
Liothyronine: ≤2.00% |
0.20% |
|
N-Acetyl-T4: ≤0,20% |
0.10% |
|
Any other individual impurity: ≤0,50% |
Соответствует |
|
Всего примесей: ≤2.00% |
1.08% |
Анализ
(HPLC basis on drying) |
97.0%~103,0% |
99.7% |
| Reference Standard |
In-house Standard |
| Заключение |
The product complied to In-house standard. |
| Хранилище |
Preserve in tight,light-resistant containers in a cool place |
