نام محصول:Levothyroxine sodium
CAS:55-03-8
MF:C15H20I4NNaO9
مگاوات:888.93
EINECS:200-221-4
فایل مول:55-03-8.مول نقطه ذوب:207-210 (دسامبر)(روشن شد)
alpha D20 -4.4° (c = 3 در 70% اتانول)
Density d420 2.381
دمای ذخیره سازی. 2-8درجه سانتی گراد
Thyroxine Soduim Salt is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine
This product is thyroid hormone replacement therapy. Function and application: It is a synthetic sodium salt of IV-thyronine. Its function and application are similar to that of thyroid tablets. Its oral absorption is 50%, its onset is slow, steady and similar to physiological hormone, which is suitable for the substitution therapy of thyroid hormone. For simple goiter, and thyroidectomy after taking, can prevent the recurrence of goiter, but also can be used as a variety of causes of hypothyroidism and other supplementary treatment.
| خصوصیات |
White or pale yellow crystalline powder |
مطابقت دارد |
| شناسایی |
توسط آی آر |
مطابقت دارد |
|
توسط HPLC |
مطابقت دارد |
| حلالیت |
Soluble in acid and alkali solution and water, slightly soluble in ethanol, insoluble in chloroform and ether |
مطابقت دارد |
| چرخش خاص |
-5.0°~-6.0° |
-5.2درجه |
| محتوای آب |
≤11.0% |
7.2% |
| Iodides Content |
≤0.08% |
مطابقت دارد |
| مواد مرتبط |
Liothyronine: ≤2.00% |
0.20% |
|
N-Acetyl-T4: ≤0.20% |
0.10% |
|
Any other individual impurity: ≤0.50% |
مطابقت دارد |
|
کل ناخالصی ها: ≤2.00% |
1.08% |
سنجش
(HPLC basis on drying) |
97.0%~ 103.0٪ |
99.7% |
| استاندارد مرجع |
استاندارد داخلی |
| نتیجه گیری |
این محصول با استاندارد داخلی مطابقت دارد. |
| ذخیره سازی |
Preserve in tight,light-resistant containers in a cool place |