Ime izdelka:Natrijev levotiroksin
CAS:55-03-8
MF:C15H20I4NNaO9
MW:888.93
EINECS:200-221-4
Datoteka Mol:55-03-8.mol Tališče:207-210 (dec.)(lit.)
alpha D20 -4.4° (c = 3 v 70% etanol)
Density d420 2.381
skladiščna temp. 2-8°C
Thyroxine Soduim Salt is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine
This product is thyroid hormone replacement therapy. Function and application: It is a synthetic sodium salt of IV-thyronine. Its function and application are similar to that of thyroid tablets. Its oral absorption is 50%, its onset is slow, steady and similar to physiological hormone, which is suitable for the substitution therapy of thyroid hormone. For simple goiter, and thyroidectomy after taking, can prevent the recurrence of goiter, but also can be used as a variety of causes of hypothyroidism and other supplementary treatment.
| Značilnosti |
White or pale yellow crystalline powder |
Ustreza |
| Identifikacija |
Z IR |
Ustreza |
|
S HPLC |
Ustreza |
| Topnost |
Soluble in acid and alkali solution and water, rahlo topen v etanolu, insoluble in chloroform and ether |
Ustreza |
| Specifična rotacija |
-5.0°~-6.0° |
-5.2° |
| Vsebnost vode |
≤11.0% |
7.2% |
| Iodides Content |
≤0.08% |
Ustreza |
| Sorodne snovi |
Liothyronine: ≤2.00% |
0.20% |
|
N-Acetyl-T4: ≤0,20 % |
0.10% |
|
Any other individual impurity: ≤0,50 % |
Ustreza |
|
Skupne nečistoče: ≤2.00% |
1.08% |
Test
(HPLC na osnovi sušenja) |
97.0%~103,0 % |
99.7% |
| Referenčni standard |
Interni standard |
| Zaključek |
Izdelek je bil skladen z internim standardom. |
| Shranjevanje |
Shranjujte v tesnem,v svetlobno odpornih posodah na hladnem |
