Nombre del producto:Levothyroxine sodium
CAS:55-03-8
MF:C15H20I4NNaO9
megavatio:888.93
EINECS:200-221-4
Archivo Mol:55-03-8.mol Melting point:207-210 (dic.)(iluminado.)
alpha D20 -4.4° (c = 3 in 70% ethanol)
Density d420 2.381
temperatura de almacenamiento. 2-8°C
Thyroxine Soduim Salt is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine
This product is thyroid hormone replacement therapy. Function and application: It is a synthetic sodium salt of IV-thyronine. Its function and application are similar to that of thyroid tablets. Its oral absorption is 50%, its onset is slow, steady and similar to physiological hormone, which is suitable for the substitution therapy of thyroid hormone. For simple goiter, and thyroidectomy after taking, can prevent the recurrence of goiter, but also can be used as a variety of causes of hypothyroidism and other supplementary treatment.
| Características |
White or pale yellow crystalline powder |
Cumple |
| Identificación |
By IR |
Cumple |
|
By HPLC |
Cumple |
| Solubilidad |
Soluble in acid and alkali solution and water, slightly soluble in ethanol, insoluble in chloroform and ether |
Cumple |
| Rotación específica |
-5.0°~-6.0° |
-5.2° |
| Contenido de agua |
≤11.0% |
7.2% |
| Iodides Content |
≤0.08% |
Cumple |
| Sustancias relacionadas |
Liothyronine: ≤2,00% |
0.20% |
|
N-Acetil-T4: ≤0,20% |
0.10% |
|
Cualquier otra impureza individual: ≤0,50% |
Cumple |
|
Impurezas totales: ≤2,00% |
1.08% |
Ensayo
(Base HPLC sobre secado.) |
97.0%~103,0% |
99.7% |
| Estándar de referencia |
Estándar interno |
| Conclusión |
El producto cumplió con el estándar interno.. |
| Almacenamiento |
Preservar firmemente,recipientes resistentes a la luz en un lugar fresco |
