Nesiritide Acetat CAS:114471-18-0

Nesiritide (Natrecor) este forma recombinantă a 32 aminoacid peptidă natriuretică umană de tip B, care este produsă în mod normal de miocardul ventricular. Nesiritide works to facilitate cardiovascular fluid homeostasis through counterregulation of the renin-angiotensin-aldoesterone system, stimularea guanozin monofosfatului ciclic, conducând la relaxarea celulelor musculare netede.

Neseritide was believed initially to be beneficial for acute decompensated congestive heart failure. A primit aprobarea de la Food and Drug Administration din Statele Unite în acest scop 2001 după neaprobarea inițială. În iulie 2011 the results of the largest study so far for nesiritide was published in The New England Journal of Medicine; it showed that nesiritide was not associated with a change in mortality or re-hospitalizations.

Mainly has a strong angiotensin II vasoconstriction and increase in blood pressure. The mechanism is: 1. So that the body arteriole smooth muscle contraction, increased peripheral resistance; 2. So increase the release of adrenal aldosterone, causing sodium retention, increased blood volume; 3. Directly contribute to renal tubular sodium and water reabsorption; 4. So the brain central nervous sympathetic vasoconstrictor activity, causing increased peripheral vascular resistance; 5. Stimulate the adrenal medulla to release epinephrine and norepinephrine.