Nesiritide Acetate CAS:114471-18-0

نسیریتید (Natrecor) شکل نوترکیب است 32 اسید آمینه پپتید ناتریورتیک نوع B انسانی, که به طور معمول توسط میوکارد بطنی تولید می شود. Nesiritide works to facilitate cardiovascular fluid homeostasis through counterregulation of the renin-angiotensin-aldoesterone system, تحریک کننده گوانوزین مونوفسفات حلقوی, منجر به شل شدن سلول های ماهیچه صاف می شود.

Neseritide was believed initially to be beneficial for acute decompensated congestive heart failure. برای این منظور از سازمان غذا و داروی ایالات متحده تاییدیه دریافت کرد 2001 پس از عدم تایید اولیه. در ماه جولای 2011 the results of the largest study so far for nesiritide was published in The New England Journal of Medicine; it showed that nesiritide was not associated with a change in mortality or re-hospitalizations.

Mainly has a strong angiotensin II vasoconstriction and increase in blood pressure. The mechanism is: 1. So that the body arteriole smooth muscle contraction, increased peripheral resistance; 2. So increase the release of adrenal aldosterone, causing sodium retention, increased blood volume; 3. Directly contribute to renal tubular sodium and water reabsorption; 4. So the brain central nervous sympathetic vasoconstrictor activity, causing increased peripheral vascular resistance; 5. Stimulate the adrenal medulla to release epinephrine and norepinephrine.