Proparacaine HCL CAS:5875-06-9

Proparacaine hydrochloride is an ester topical anesthetic. Its mechanism of action is to reduce the instantaneous permeability of neurons to sodium, stabilize nerve cell membranes, and prevent the generation and conduction of nerve electrical impulses, thereby producing anesthesia. Block pain fibers first, then block temperature, touch, and deep sensory fibers. Thin nerve fibers are more sensitive than thick nerve fibers and take longer to recover. The anesthetic strength of this medicine is slightly higher than the same concentration of tetracaine, and the effect is fast.

Proparacaine Hydrochloride Ophthalmic Solution is indicated for topical anesthesia in ophthalmic practice. Representative ophthalmic procedures in which the preparation provides good local anesthesia include measurement of intraocular pressure (tonometry), removal of foreign bodies and sutures from the cornea, conjunctival scraping in diagnosis and gonioscopic examination; it is also indicated for use as a topical anesthetic prior to surgical operations such as cataract extraction.