Eledoisin Acetate
CAS Subcriptio Number: 69-25-0
Gradus: Pharmceutical Grade
Formulae hypotheticae: C54H85N13O15S
M. Pondus: 1188.44
Puritas (HPLC): 99.0%
Aspectus: Pulvis albus
una immunditia(HPLC): 0.5%
Amino Acidum Compositio: 10% theoretical
Peptide Content(N%): 80%(by %N)
Aqua Content(Carolus Fischer): 6.0%
Acetate Content(HPIC): 15.0%
Eledoisin est undecapeptide mollusk originis, ad tachykinin familia neuropeptides.
Primum a glandulis salivaris posterioris duarum specierum molluscarum Eledone muschatae separatae et Eledone aldovandi., quae ad ordinem octopodum pertinent.
Alia tachykinina e fontibus nonmammalianis includunt kassinin et physalaemin. Mammalia tachykinins substantia P, ACCIPITE, et NKB similes effectus cum tachykinis nonmammalibus habent et latius pervestigatae sunt et characteristae. Hae peptides exhibent spectrum amplum et multiplex actionis pharmacologicae et physiologicae, sicut vasodilation, hypertension, et excitanda musculi extravasati lenis.
Eledoisin habet amino acidi sequentiam pGlu-Pro Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2 (qPSKDAFIGLM-NH2) ubi pGlu et q consistunt pro acido pyroglutamico. Sicut omnes tachykinin peptides, Eledoisin eundem consensum C-terminalem consequentiam communicat, hoc est, Phe-Xxx-Gly-Leu-Met-NH. immutatus "Phe7" residuum probabiliter requisiti receptor binding. "XXX" aut aromaticum (phenylalanine, tyrosine) aut ramosis aliphaticis (valine, isoleucine) latus catenae et magni momenti putatur in receptore selectivity. Hoc commune regionis, saepe referred to as "nuntius domain," reus esse creditur activum receptor. In divergentibus N-terminus regionis vel "oratio domain" varies in amino-acid sequence and length and is believed to play a role in determining the receptor subtype specificity.
