Eledoisin Acetate
CAS-registernommer: 69-25-0
Graad: Farmseutiese Graad
Molekulêre Formule: C54H85N13O15S
Molekulêre gewig: 1188.44
Reinheid (HPLC): 99.0%
Voorkoms: Wit poeier
Enkele Onreinheid(HPLC): 0.5%
Aminosuur samestelling: 10% van teoretiese
Peptied inhoud(N%): 80%(deur %N)
Waterinhoud(Karl Fischer): 6.0%
Asetaat inhoud(HPIC): 15.0%
Eledoisin is 'n undekapeptied van weekdier oorsprong, behoort aan die tachykinienfamilie van neuropaptiede.
Dit is eers geïsoleer uit die posterior speekselkliere van twee weekdierspesies Eledone muschata en Eledone aldovandi, wat aan die seekat-orde van Cephalopoda behoort.
Ander tachykiniene uit niesoogdierbronne sluit kassinien en fisalaemin in. Die soogdier tachykiniene stof P, NEEM, en NKB het soortgelyke effekte as tagykiniene van niesoogdiere en is meer wyd bestudeer en gekarakteriseer. These peptides exhibit a wide and complex spectrum of pharmacological and physiological activities such as vasodilation, hipertensie, and stimulation of extravascular smooth muscle.
Eledoisin has the amino acid sequence pGlu-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2 (qPSKDAFIGLM-NH2) where pGlu and q stand for pyroglutamic acid. Like all tachykinin peptides, Eledoisin shares the same consensus C-terminal sequence, dit wil sê, Phe-Xxx-Gly-Leu-Met-NH. The invariant "Phe7" residue is probably required for receptor binding. "Xxx" is either an aromatic (phenylalanine, tirosien) or a branched aliphatic (valine, isoleusien) side chain and is thought to be important in receptor selectivity. This common region, often referred to as the "message domain," is believed to be responsible for activating the receptor. The divergent N-terminal region or the "address domain" varies in amino-acid sequence and length and is believed to play a role in determining the receptor subtype specificity.
