Folinic acid (INN) or leucovorin (USAN), generally administered as calcium or sodium folinate(or leucovorin calcium/sodium), is an adjuvant used in cancer chemotherapy involving the drug methotrexate. It is also used in synergistic combination with the chemotherapy agent 5-fluorouracil.
Folinic acid was first discovered in 1948 as citrovorum factor and occasionally is still called by that name. Folinic acid should be distinguished from folic acid (vitamin B9). Egter, folinic acid is a vitamer for folic acid and has the full vitamin activity of this vitamin. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Levofolinic acid and its salts are the 2S- a form of the molecule. They are the only molecules that are biologically active.
1.It is mainly used as the antidote of folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, ens.).
2.It can be used for the prevention of severe toxicity after excessive or large doses administration of methotrexate.
3.The megaloblastic anemia caused by folic acid deficiency.
4.In combination with fluorouracil, dit word gebruik vir die behandeling van gevorderde kolonkanker en rektale kanker.
Dit word gebruik vir die redding van die toksisiteitsreaksie wat veroorsaak word deur oormatige hoeveelheid aminopterien en metotreksaat, sowel as vir die behandeling van reuse-rooibloedselle-anemie.
5.Die doeltreffendheid van folaat kan die effekte van foliensuurantagoniste verreken. Die foliensuurantagoniste maak staat op binding aan foliensuurdehidrogenase (DHFR), daardeur voorkom dat folaat na foliensuur omskakel. Medies, na die chemoterapie van metotreksaat, die kalsiumfolinaat kan gebruik word om metotreksaattoksisiteit te verminder. Kalsiumfolinaat kan gebruik word om die sitotoksiese effek van 5-fluorouracil in kankervelde te verbeter.
