Cyproheptadine Hydrochloride
Номер CAS. : 969-33-5
Молекулярна формула: C21H22ClN
Молекулярна маса: 323.86
EINECS NO: 213-535-1
Cyproheptadine hydrochloride, also known as dibenzocycloheptadine, antigentadine, is a hexahydropyridine antihistamine, which can compete with histamine released from tissues for H1 receptors on effector cells, thus preventing the onset of allergic reactions and relieving the spasmogenic and congestive effects of histamine, which has a strong H1 receptor antagonistic effect and stronger antihistamine effect than paracetamol and promethazine. It has mild to moderate anti-5-hydroxytryptamine effect and anticholinergic effect.
Крім того, Cyproheptadine hydrochloride also has the effect of stimulating appetite, and weight gain can be seen after taking for a certain period of time.
Cyproheptadine hydrochloride is a white or yellowish crystalline powder, almost odorless, with a slightly bitter taste. It is soluble in methanol, dissolved in chloroform, slightly soluble in ethanol, slightly soluble in water and almost insoluble in ether.
Clinically, cyproheptadine hydrochloride is mainly used for acute and chronic urticaria (especially cold urticaria has good effect), papular urticaria, angioedema, allergic eczema, контактний дерматит, food allergic reaction, drug allergic reaction, алергічний риніт, hay fever, allergic nodular inflammation, insect sting allergy and migraine.
Cyproheptadine hydrochloride has some therapeutic effect on bronchial asthma. It can also be used as an adjuvant treatment for Cushing's syndrome and acromegaly.
Cyproheptadine hydrochloride can also be used as an appetite enhancer for neurotic appetite fear.
Cyproheptadine hydrochloride has also been reported for the treatment of acanthosis nigricans and the prevention of necrotizing pyoderma.
| ПРЕДМЕТИ АНАЛІЗУ |
ТЕХНІЧНІ ХАРАКТЕРИСТИКИ |
РЕЗУЛЬТАТ |
| Зовнішній вигляд |
White to slightly yellow, odorless or
practically odorless, кристалічний порошок. |
Білий кристалічний порошок |
| Ідентифікація |
І:The infrared absorption spectrum of the potassium bromide dispersion of the sample exhibits maxima only at the same wavelengths as that of a similar preparation of Cyproheptadine Hydrochloride reference standard |
Відповідає |
| ВЕРХ:The retention time of the cyproheptadine peak of the sample solution corresponds to that of the standard solution, as obtained in the test for organic impurities |
Відповідає |
| A saturated solution gives reaction of chlorides |
Відповідає |
| Розчинність |
Freely soluble in methanol, sparingly soluble in chloroform, помірно розчинний у спирті, slightly soluble in water practically insoluble in ether. |
Відповідає |
| Fluorescence Test |
To comply |
Відповідає |
| Residue of Ignition |
≤ 0.1% |
0.07% |
| Сульфатна зола |
≤ 0.1% |
0.08% |
| Світлопоглинаючі домішки |
At 490nm ≤ 0.07 |
0.04 |
| Organic Impurities by HPLC |
Cyproheptadine related compound C: ≤ 0.15% |
Не виявлено |
| Amitriptyline related compound B ≤ 0.15% |
Не виявлено |
| Cyproheptadine related compound A ≤ 0.15% |
0.05% |
| Any individual unknown Impurity ≤ 0.1% |
0.05% |
|
Загальна кількість домішок ≤0,5% |
0.13% |
| Кислотність |
NMT 0.15 ml of 0.01 M sodium Hydroxide is
required to change the co lour of the indicator
|
0.1мл |
| Water Determination |
7.0% до 9.0% |
8.5% |
| Залишкові розчинники |
Methanol ≤300ppm |
163ppm |
| O-rylene ≤2170ppm |
Не виявлено |
| lsopropyl alcohol ≤5000ppm |
24ppm |
| Toluene ≤890ppm |
Не виявлено |
| Tetrahydrofuran ≤720ppm |
Не виявлено |
| Chloroform ≤60ppm |
Не виявлено |
| аналіз (Dry based) |
98.5%~100,5% |
100.2% |
| Висновок |
Complies with the USP40 standard |
