Navn: Fluocinolonacetonid
CAS-nr.: 67-73-2
Formel: C24H30F2O6
Molekylvekt: 452.54
Synonymer: Pregna-1,4-diene-3,20-dione,6en,9-difluoro-11b,16en,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone(6CI,8CI); 6en,9a-Difluoro-16a,17a-isopropylidenedioxy-D1-hydrocortisone;6en,9a-Difluoro-16a-hydroxyprednisolone16,17-acetonide;6a-Fluorotriamcinolone acetonide; Coriphate;Cortiplastol;Dermalar;Dermatin;Dermatin (steroid);Fluocinolone 16,17-acetonide;Fluovitef;Fluvean;Jellin;Localyn;NSC 92339;Percutina;Sinaflan;Sinalar;
EINECS: 200-668-5
Tetthet: 1.36 g/cm3
Smeltepunkt: 267-269 °C(lit.)
Kokepunkt: 578.5 °C kl 760 mmHg
Flammepunkt: 303.7 °C
Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. Den ble først syntetisert i 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01-0.025%. One such cream is sold under the brand name Flucort-N and includes the antibioticneomycin.
Fluocinolone acetonide was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone.
