Флуоцинолона ацетонид CAS:67-73-2

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. Впервые он был синтезирован в 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01-0.025%. One such cream is sold under the brand name Flucort-N and includes the antibioticneomycin.

Fluocinolone acetonide was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone.

• Fluocinolone acetonide is used to decrease inflammation in the skin.
• It is a corticosteroid, sometimes known as a steroid.
• In general this drug is used to treat inflammatory skin disorders such aseczema and psoriasis.
• Benefits of being on this drug can include reduction of inflammation and relief of itch.