Nome: Acetonido de fluocinolona
Nº CAS: 67-73-2
Fórmula: C24H30F2O6
Peso molecular: 452.54
Sinônimos: Pregna-1,4-dieno-3,20-diona,6um,9-difluoro-11b,16um,17,21-tetrahidroxi-, 16,17-acetal cíclico com acetona(6IC,8IC); 6um,9a-Difluoro-16a,17a-isopropilidenodioxi-D1-hidrocortisona;6um,9a-Difluoro-16a-hidroxiprednisolona16,17-acetonido;6Acetonido de a-fluorotriamcinolona; Corifado;Cortiplastol;Dermas;Dermatina;Dermatina (esteroide);Fluocinolona 16,17-acetonido;Fluovitef;Fluviano;gelatina;Localyn;NSC 92339;Percutina;Sinaflan;apontar;
EINECS: 200-668-5
Densidade: 1.36 g/cm3
Ponto de fusão: 267-269 °C(aceso.)
Ponto de ebulição: 578.5 °C em 760 mmHg
Ponto de inflamação: 303.7 °C
Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. Foi sintetizado pela primeira vez em 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01-0.025%. One such cream is sold under the brand name Flucort-N and includes the antibioticneomycin.
Fluocinolone acetonide was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone.
