Namn: Fluocinolone acetonide
CAS-nr.: 67-73-2
Formel: C24H30F2O6
Molekylvikt: 452.54
Synonymer: Pregna-1,4-dien-3,20-dion,6a,9-difluoro-llb,16a,17,21-tetrahydroxi-, cyklisk 16,17-acetal med aceton(6CI,8CI); 6a,9a-Difluoro-16a,17a-isopropylidendioxi-Dl-hydrokortison;6a,9a-Difluoro-16a-hydroxiprednisolon16,17-acetonid;6a-fluortriamcinolonacetonid; Korifat;Cortiplastol;Dermas;Dermatin;Dermatin (steroid);Fluocinolon 16,17-acetonid;Fluovitef;Fluvean;Jellin;Localyn;NSC 92339;Percutina;Sinaflan;påpeka;
EINECS: 200-668-5
Densitet: 1.36 g/cm3
Smältpunkt: 267-269 °C(belyst.)
Kokpunkt: 578.5 °C kl 760 mmHg
Flampunkt: 303.7 °C
Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. Det syntetiserades först i 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01-0.025%. One such cream is sold under the brand name Flucort-N and includes the antibioticneomycin.
Fluocinolone acetonide was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone.
