Nume: Fluocinolone acetonide
CAS Nr.: 67-73-2
Formula: C24H30F2O6
Greutate moleculară: 452.54
Sinonime: Pregna-1,4-diene-3,20-dione,6o,9-difluoro-11b,16o,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone(6CI,8CI); 6o,9a-Difluoro-16a,17a-isopropylidenedioxy-D1-hydrocortisone;6o,9a-Difluoro-16a-hydroxyprednisolone16,17-acetonide;6a-Fluorotriamcinolone acetonide; Coriphate;Cortiplastol;Dermalar;Dermatin;Dermatin (steroid);Fluocinolone 16,17-acetonide;Fluovitef;Fluvean;Jellin;Localyn;NSC 92339;Percutina;Sinaflan;Sinalar;
EINECS: 200-668-5
Densitate: 1.36 g/cm3
Punct de topire: 267-269 °C(aprins.)
Punct de fierbere: 578.5 °C la 760 mmHg
Punct de aprindere: 303.7 °C
Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A fost sintetizat pentru prima dată în 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01-0.025%. One such cream is sold under the brand name Flucort-N and includes the antibioticneomycin.
Fluocinolone acetonide was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone.
