Tetracaine (GOSTILNA, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Tetracaine HCL is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction.
Tetracaine Hcl is a potent local anesthetic of the ester group.It is mainly used topically in ophthalmology and as an antipruritic,and it has been used in spinal anesthesia.
Tetracaine hydrochloride is indicated for the production of spinal anesthesia for procedures requiring two to three hours.
Za profil učinkovitosti lidokaina kot lokalnega anestetika je značilen hiter začetek delovanja in vmesno trajanje učinkovitosti.. Zato, lidokain je primeren za infiltracijo, blok, in površinsko anestezijo. Dolgodelujoče snovi, kot je bupivakain, imajo včasih prednost pri subduralni in epiduralni anesteziji; lidokain,čeprav, ima prednost hitrega začetka delovanja.
In dental anesthesia, relativna neobčutljivost na lidokain se lahko pojavi zaradi anatomskih razlogov zaradi nepričakovanih položajev živcev. Nekateri ljudje z Ehlers-Danlosovim sindromom so neobčutljivi na lidokain.
