Bupivacaine hydrochloride (anhydrous) is a racemate composed of equimolar amounts of dextrobupivacaine hydrochloride and levobupivacaine hydrochloride. The monohydrate form is commonly used as a local anaesthetic. It has a role as an adrenergic antagonist, an amphiphile, an EC 3.1.1.8 (cholinesterase) inhibeerder, an EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor and a local anaesthetic. It contains a levobupivacaine hydrochloride (anhydrous), a dextrobupivacaine hydrochloride (anhydrous) and a bupivacaine(1+).
Bupivacaine Hydrochloride is available in sterile isotonic solutions with and without epinephrine (as bitartrate) 1:200,000 vir inspuiting via plaaslike infiltrasie, perifere senuwee blok, en caudale en lumbale epidurale blokke. Oplossings van Bupivacaine Hydrochloride kan geoutoklaveer word as dit nie epinefrien bevat nie. Oplossings is helder en kleurloos.
Bupivacaine is chemies en farmakologies verwant aan die aminoasiel plaaslike verdowingsmiddels. Dit is 'n homoloog van mepivakaïen en is chemies verwant aan lidokaïen. Al drie hierdie narkosemiddels bevat 'n amiedbinding tussen die aromatiese kern en die amino, of piperidiengroep. Hulle verskil in hierdie opsig van die prokaïentipe lokale verdowingsmiddels, wat 'n esterbinding het.
