Lidokain Base CAS:137-58-6

Lidokain, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic healthcare system.

Lidocaine is the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated.

Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.

Effektprofilen til lidokain som lokalbedøvelse er preget av en rask innsettende virkning og middels varighet av effekt. Derfor, lidokain er egnet for infiltrasjon, blokkere, og overflateanestesi. Langtidsvirkende stoffer som bupivakain er noen ganger gitt preferanse for subdural og epidural anestesi; lidokain,skjønt, har fordelen av en rask innsettende virkning.

Relative insensitivity to lidocaine is genetic.In hypokalemic sensory overstimulation, relative insensitivity to lidocaine has been described in people who also have attention deficit hyperactivity disorder.In dental anesthesia, en relativ ufølsomhet for lidokain kan oppstå av anatomiske årsaker på grunn av uventede posisjoner av nerver. Noen mennesker med Ehlers-Danlos syndrom er ufølsomme for lidokain.

Lidokain, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge.