Mepivacaine Hydrochloride, a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride.
A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route.
Mepivicaine is a local anesthetic of the amide type. Mepivicaine as a reasonably rapid onset and medium duration and is known by the proprietary names as Carbocaine and Polocaine. Mepivicaine is used in local infiltration and regional anesthesia. Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems. At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal.
Mupivacaine hydrochloride to stabilize the neuronal membrane, to prevent the occurrence and spread of nerve impulses, and thus local anesthesia.
The rapid metabolism of mepivacaine hydrochloride, only a small part of the anesthetic (5% til 10%) excretion in the urine unchanged. Metapin avgiftes ikke av sirkulerende plasmaesterase på grunn av dets amidstruktur. Leveren er hovedstedet for metabolisme, mer enn 50% av dosen som metabolitt skilles ut i gallen. Mest metabolisert mepivakain kan absorberes i tarmen og deretter skilles ut i urinen fordi bare en liten del finnes i avføringen.
Den viktigste måten å skille ut på er gjennom nyrene. De fleste anestetika og deres metabolitter elimineres innenfor 30 timer. Det er vist at hydroksylering og N-demetylering som avgiftning spiller en viktig rolle i metabolismen av anestetika. Tre metabolitter av mepivakain er identifisert fra voksne: to fenoler utskilles nesten fullstendig som glukuronidkonjugater, og N-demetylerte forbindelser (2 & apos;, 6 & apos; Oksygen).
