Дезоксиметилтестостерон CAS:3275-64-7

Desoxymethyltestosterone (ДМТ), known by the nicknames Madol and Pheraplex, is a synthetic and orally active anabolic–androgenic steroid (AAS) and a 17α-methylated derivative of dihydrotestosterone (DHT) which was never marketed for medical use. It was one of the first designer steroids to be marketed as a performance-enhancing drug to athletes and bodybuilders.

Desoxymethyltestosterone is sometimes abbreviated as DMT, though it should not be confused with the hallucinogen dimethyltryptamine, which is also known by the same acronym.

В проучвания върху животни, desoxymethyltestosterone has been found to bind to the androgen receptor (AR) about half as strongly as DHT, and to cause side effects that are typical of 17α-alkylated AAS, such as liver damage and left ventricular hypertrophy when taken in higher doses.

Desoxymethyltestosterone is unusual in that it is structurally a 2-ene compound, lacking the 3-keto group present in almost all commercial AAS (with ethylestrenol being a rare and notable exception). This does not mean it is a weak compound, and clinical research has determined that it is a fairly potent oral agent.[2] Rat studies indicate that desoxymethyltestosterone has an anabolic effect 160% that of testosterone while being only 60% as androgenic, giving it a Q ratio of 6.5:1.[3] Because of this favorable ratio, експерименти с орхиектомирани плъхове показват, че лечението с дезоксиметилтестостерон води само до стимулиране на теглото на повдигащия ани мускул; теглото на простатата и семенните везикули остава незасегнато, което кара авторите на едно проучване да характеризират дезоксиметилтестостерона като мощен AAS с атрибути на селективен модулатор на андрогенни рецептори (SARM) и някои признаци на токсичност.