ε-polylysine (ε-PL) is a natural isomorphic polymer of lysine, composed of ε-amidogen and α-carboxyl of another lysine connected by peptide bond. Among all existing natural preservatives, ε-PL enjoys excellent antiseptic property and great commercial potential, known for a wide antibacterial spectrum, high safety performance, admirable thermostability and convenient use. By far, ε-PL has been applied to rice, box lunch, ケーキ, household cooking, soy sauce, spice and vegetable washing liquid, 等. ε-PL obtained FDA license in 2003 and is expected of further development in the coming years. 加えて, ε-PL is known for good water solubility, biodegradability, agreeable flavor and no harm to human body and the environment. ε-PL and its derivatives allow a wide range of applications including food preservative agent, emulsifier, dietary agent, biodegradable fiber, high-perfomance hydrogel, drug carrier, anticarcinogen and biochip coating.
Application in Food Industry
Currently, ε-PL is primarily applied in the food industry, especially in food preservation, emulsifier and nutrient due to the excellent performance.
In light of the antimicrobial property and high safety, ε-PL has been widely applied to all aspects of the food industry. In Japan, ε-PL is adopted for preservation of fast food, dairy product, pastry, sauce, 飲み物, wine, 肉, seafood, sausage and poultry. お弁当や主食以外の食品にも, ε-PLは酵母の増殖を抑制します, 悪臭を防ぎ、製品の保存寿命を延ばします.
ブドウ糖と協力して働く, ε-PLは乳化剤と抗菌剤の二機能を応用.
ε-PLは膵リパーゼ活性を阻害することで脂肪の吸収を抑え、肥満を予防します。.
生物医学への応用
生物医学において, ε-PLは主に薬物キャリアに使用されます, エンドトキシン除去剤とバイオセンサー.
ポリソームイノシン酸およびポリソームシチジル酸によって合成される二本鎖RNAと連携して、内因性インターフェロン誘導物質として機能します。.
抗葉酸メトトレキサートや抗がん剤と併用して白血病を治療することができます。, 肉腫, 新しい腫瘍と白癬菌に対する耐性.
ウイルスフリーの遺伝子運搬体.
リポ多糖類エンドトキシン除去剤.
血清および肝臓のコレステロールを阻害し、減少させます。.
バイオセンサーに使用される酵素を固定化します.
