نام محصول :سالمون کلسی تونین
نام تجاری:Saleatonin
شماره CAS:47931-85-1
فرمول مولکولی: C145H240N44O48S2
وزن مولکولی:3431.85g/mol
خلوص : 98% HPLC
ظاهر: Lyophilized Powder
Typical use:Treatment of Osteoporosis
کلسی تونین (salmon) is an hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Calcitonin decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. Alternative splicing of the calcitonin pre-mRNA can yield a mRNA encoding calcitonin gene-related peptide; that peptide appears to function in the nervous and vascular systems. The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.
-Treatment of postmenopausal women with osteoporosis at high risk for fracture
-Increase of bone mass in men with primary or hypogonadal osteoporosis at high risk for fracture
-Treatment of men and women with osteoporosis associated with sustained systemic glucocorticoid therapy at high risk for fracture
| مورد |
استاندارد |
نتایج آزمون |
| شناسایی |
A.H-NMR:Comply with the structure |
مطابقت دارد |
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B.LC-MS:Comply with the structure |
مطابقت دارد |
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C.The IR spectrum of sample should be identical with that of reference standard; |
مطابقت دارد |
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D.HPLC-ESI-MS
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. |
مطابقت دارد |
| Crystallinity |
meets the requirements. |
مطابقت دارد |
| ضرر در خشک شدن |
≤2.0٪ |
0.19% |
| فلزات سنگین |
≤10 ppm |
<10ppm |
| آب |
≤1.0٪ |
0.1% |
| خاکستر سولفاته |
≤0.5٪, determined on 1.0 g. |
0.009% |
| مواد مرتبط |
ناخالصی های نامشخص: for each impurity |
<0.10% |
|
Total Impurity |
0.18% |
| خلوص |
≥99.0٪ |
99.7% |
| سنجش |
99.0%~ 101.0٪ (anhydrous substance). |
99.8% |
| Microbiological Analysis |
|
|
| تعداد کل بشقاب |
≤1000cfu/g |
مطابقت دارد |
| Yeast and Moulds |
≤100cfu/g |
مطابقت دارد |
| E. کولی. |
Absent |
منفی |
| سالمونلا |
Absent |
منفی |
| S.aureus |
Absent |
منفی |
| ذخیره سازی |
Preserve in well-closed, light-resistant and airtight containers. |
مطابقت دارد |
