Mepivacaine Hydrochloride, a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride.
A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nervus obstructionum, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route.
Mepivicaine est locus Papaverus generis amidi. Mepivicaine sicut rationabiliter rapido impetu et mediante duratione, et cognoscitur nominibus proprietatis sicut Carbocaine et Polocaine.. Mepivicaine adhibetur in infiltratione locali et anesthesia regionali. Effusio systemica anestheticorum localium effectus producit in systematibus nervosis cardiovascularibus et centralibus. In sanguinem concentratione effectum cum gustatu normali medicinalis, mutat in cardiac conduction, excitability, refractio, contractum, vascularium et periphericum resistentia minima.
Mupivacaine hydrochloride ad stabiliendum membranam neuronalem, ne fiat et propagationem nervi motus, et sic loci anesthesia.
Rapidum metabolismi hydrochloridi mepivacaini, nisi parva pars Papaver (5% to 10%) excretio in urina mutatum. Methapinum plasma esterasum propter inter structuram non detoxatur. Iecur metabolismi principale situm est, plus quam 50% dose sicut metabolitae in bilem redduntur. Maxime metabolized mepivacaine potest absorberi in intestino et deinde in urinam excerni, quia exigua pars in faecibus exturbatur..
Praecipua via est per renes excreandi. Pleraque anesthetica et eorum metabolitae intus eliminantur 30 horae. Ostensum est hydroxylationem et N-demethylationem tamquam detoxificationem in metabolismi anestheticorum magni ponderis partes agere.. Tres metabolitae mepivacaenarum ab adultis notae sunt: duo phenols fere penitus excernuntur ut conjugates glucuronides, and N-demethylated compounds (2 & apos;, 6 & apos; Oxygen).
