Base de tetracaína CAS:94-24-6

Tetracaine (POSADA, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. Está en la Lista de Medicamentos Esenciales de la Organización Mundial de la Salud., una lista de los medicamentos más importantes necesarios en un sistema básico de salud.

(1) In biomedical research, tetracaine is used to alter the function of calcium release channels (receptores de rianodina) que controlan la liberación de calcio de las reservas intracelulares. La tetracaína es un bloqueador alostérico de la función del canal.. En bajas concentraciones, La tetracaína provoca una inhibición inicial de los eventos de liberación espontánea de calcio., mientras que en altas concentraciones, Los bloques de tetracaína se liberan completamente..

(2) Tetracaine is the T in Tac, a mixture of 5 a 12 per cent tetracaine, 5METRO(per myriad), a half per mille (0.5‰), o .05 por ciento (1 part in 2000) , y 4 o 10 per cent hydrochloride used in ear, nariz & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, oreja, or other sensitive locations.

(3) Tetracaine is synthesized from 4-butylaminobenzoic acid. El éster etílico se forma mediante una reacción de esterificación catalizada por ácido.. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

Before using Tetracaine, barbiturates should be taken first. A small amount of adrenaline should be added into Anesthetic to improve capillary contraction, and decrease drug absorption.

You should make a trial before using topical anesthetic. Only without allergic reaction can appropriate amount be used.In biomedical research, tetracaine is used to alter the function of calcium release channels (receptores de rianodina) que controlan la liberación de calcio de las reservas intracelulares. La tetracaína es un bloqueador alostérico de la función del canal.. En bajas concentraciones, La tetracaína provoca una inhibición inicial de los eventos de liberación espontánea de calcio., mientras que en altas concentraciones, tetracaine blocks release completely.Used for mucosal epidermal anesthesia, nerve tissue anesthesia, epidural anesthesia and Subarachnoid space anesthesia.In the manufacture of pharmaceutical preparation for external use, to relieve the pain of drugs or medication lesions pain.

La tetracaína HCL se sintetiza a partir del ácido 4-butilaminobenzoico.. El éster etílico se forma mediante una reacción de esterificación catalizada por ácido.. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

Tetracaine is the T in Tac, a mixture of 5 a 12 per cent tetracaine, 5METRO(per myriad), a half per mille (0.5‰), o .05 por ciento (1 part in 2000) , y 4 o 10 per cent hydrochloride used in ear,nariz & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, oreja, or other sensitive locations.