Product Name :Calcitonin salmon
Trade Name:Saleatonin
CAS No.:47931-85-1
Molecular Formula: C145H240N44O48S2
Molecular Weight:3431.85g/mol
Purity : 98% HPLC
Appearance: Lyophilized Powder
Typical use:Treatment of Osteoporosis
Calcitonin (salmon) is an hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Calcitonin decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. Alternative splicing of the calcitonin pre-mRNA can yield a mRNA encoding calcitonin gene-related peptide; that peptide appears to function in the nervous and vascular systems. The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.
-Treatment of postmenopausal women with osteoporosis at high risk for fracture
-Increase of bone mass in men with primary or hypogonadal osteoporosis at high risk for fracture
-Treatment of men and women with osteoporosis associated with sustained systemic glucocorticoid therapy at high risk for fracture
| Item |
Standard |
Test Results |
| Identification |
A.H-NMR:Comply with the structure |
Complies |
|
B.LC-MS:Comply with the structure |
Complies |
|
C.The IR spectrum of sample should be identical with that of reference standard; |
Complies |
|
D.HPLC-ESI-MS
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. |
Complies |
| Crystallinity |
meets the requirements. |
Complies |
| Loss on drying |
≤2.0% |
0.19% |
| Heavy metals |
≤10 ppm |
<10ppm |
| Water |
≤1.0% |
0.1% |
| Sulphated ash |
≤0.5%, determined on 1.0 g. |
0.009% |
| Related substances |
Unspecified impurities: for each impurity |
<0.10% |
|
Total Impurity |
0.18% |
| Purity |
≥99.0% |
99.7% |
| Assay |
99.0%~101.0% (anhydrous substance). |
99.8% |
| Microbiological Analysis |
|
|
| Total plate count |
≤1000cfu/g |
Complies |
| Yeast and Moulds |
≤100cfu/g |
Complies |
| E. Coli. |
Absent |
Negative |
| Salmonella |
Absent |
Negative |
| S.aureus |
Absent |
Negative |
| Storage |
Preserve in well-closed, light-resistant and airtight containers. |
Complies |
