Product Name : Ornipressin Acetate
Synonyma:8-Ornithine-vasopressin
CAS#: 3397-23-7; 914453-98-8
Formulae hypotheticae: C45H63N13O*12S2
MW: 1042.19
Sequentia: H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro Orn-Gly-NH2 (Vinculum disulfide)
Aspectus: cerussa
Puritas (HPLC):≥98.0%
una immunditia (HPLC): ≤2.0%
Acetate Content(HPLC): 5.0%-12.0%
Aqua Content (Carolus Fischer): ≤10.0%
Peptide content: ≥80.0%
Ornipressin synthetica derivatio vasopressin (arginine-8-vasopressin) in quo ornithine pro arginine ad 8 positione. Fundamentum amino-acidum residuum in positione 8 de vasopressin moleculo determinat pressor et anti-diureticus effectus. Ornithine, ens et minus basic ac breve torquem amino-acidum, ligamen ornipressin ad receptores in distali tubule nephronis reducit sine ligatura recepta receptoribus in musculo vaso- culari lenis, mediante vasoconstrictione.. Sic, ornipressin habet minimam antidiureticam actionem servato aequipotent vasoconstrictor operatio sicut naturalis hormone, vasopressin.
Ornipress, quae affinitatem habet pro V*1A receptores , operatur Gs proteins, quae phospholipasem C excitant et consequuntur in naufragii membranae lipidorum ad triphosphatam inositolam (IP3) et diacylglycerol (DIES); IP3 solvo calcium endoplasmicum reticulum, augendae cytosolic calcium, DAG dapibus kinasum C quod phosphorylates cellularum proteins. Hic Caesar motus biochemicalis ducit ad sustentationem vasoconstriction. tamen, ad concentratione alto (>0.1 IU mL1), ornipressin ligat ad V*2 receptores cum V1A receptores plene saturantur. Activatio V *2 receptores consequitur in augmento cyclici AMP qui ad vasodilatationem ducit, paradoxum effectum demonstratum a Fruhstorfer et Heisler.
